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    Department of Synthetic Biology and Immunology

    Research of the molecular mechanism of molecular recognition and signaling in innate immune response, and synthetic biology.

     

    Co-workers

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    Representative Publications

    1. ZHOU, Weijun, STRMŠEK, Žiga, SNOJ, Jaka, ŠKARABOT, Miha, JERALA, Roman. Programmable protein-DNA composite nanostructures : from nanostructure construction to protein-induced micro-scale material self-assembly and functionalization. Small. 2025, 2502060, 1-12.
    2. BORŠIĆ, Elvira, ŽELEZNIK RAMUTA, Taja, OREHEK, Sara, ERDANI-KREFT, Mateja, GEYER, Matthias, JERALA, Roman, HAFNER BRATKOVIČ, Iva. Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly. Nature communications. 2025, 16, 4887, 1-18.
    3. RIHTAR, Erik, FINK, Tina, LEBAR, Tina, LAINŠČEK, Duško, ZIDAR, Živa, KADUNC POLAJNAR, Lucija, JERALA, Roman. Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes. Cell chemical biology. 20 Mar. 2025, 32, 3, 474-485, e1-e5.
    4. VIDMAR, Sara, ŠMIDLEHNER, Tamara, AUPIČ, Jana, STRMŠEK, Žiga, LJUBETIČ, Ajasja, XIAO, Fei, HU, Guang, LIU, Chuan, BECK, Florian, ERDMANN, Philipp S., JERALA, Roman. Beyond dimerization: harnessing tetrameric coiled-coils for nanostructure assembly. Angewandte Chemie international edition. 2025, 64, e202422075, 1-8.
    5. MEZGEC, Klemen, SNOJ, Jaka, ULČAKAR, Liza, LJUBETIČ, Ajasja, TUŠEK-ŽNIDARIČ, Magda, ŠKARABOT, Miha, JERALA, Roman. Coupling of spectrin repeat modules for the assembly of nanorods and presentation of protein domains. ACS nano, Oct. 22, 2024, 18, 42, 28748–28763.
    6. SNOJ, Jaka, LAPENTA, Fabio, JERALA, Roman. Preorganized cyclic modules facilitate the self-assembly of protein nanostructures. Chemical science. 2024, 15, 10, 3673-3686.
    7. JAZBEC, Vid, VARDA, Nina, ŠPRAGER, Ernest, MEŠKO, Maja, VIDMAR, Sara, ROMIH, Rok, PODOBNIK, Marjetka, KEŽAR, Andreja, JERALA, Roman, BENČINA, Mojca. Protein gas vesicles of bacillus megaterium as enhancers of ultrasound-induced transcriptional regulation. ACS nano. 2024, 18, 16692–16700.
    8. ESIH, Hana, MEZGEC, Klemen, BILLMEIER, Martina, MALENŠEK, Špela, BENČINA, Mojca, GRILC, Blaž, VIDMAR, Sara, GAŠPERLIN, Mirjana, BELE, Marjan, ZIDARN, Mihaela, LEJKO-ZUPANC, Tatjana, MORGAN, Tina, LAINŠČEK, Duško, JERALA, Roman, et al. Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract. Journal of controlled release, 2024, 371, 179-192.
    9. IVANOVSKI, Filip, MEŠKO, Maja, LEBAR, Tina, RUPNIK, Marko, LAINŠČEK, Duško, GRADIŠEK, Miha, JERALA, Roman, BENČINA, Mojca. Ultrasound-mediated spatial and temporal control of engineered cells in vivo. Nature communications. 2024, 15, 7369, 1-14.
    10. OREHEK, Sara, ŽELEZNIK RAMUTA, Taja, LAINŠČEK, Duško, MALENŠEK, Špela, ŠALA, Martin, BENČINA, Mojca, JERALA, Roman, HAFNER BRATKOVIČ, Iva. Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors. Nature communications. 2024, 15, 10801, 1-22.
    11. LAINŠČEK, Duško, HORVAT, Simon, DOLINAR, Klemen, IVANOVSKI, Filip, ROMIH, Rok, PIRKMAJER, Sergej, JERALA, Roman, MANČEK KEBER, Mateja. MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis. Cell communication and signaling. 2024, 22, 549, 1-14.
    12. GOVEDNIK, Tea, LAINŠČEK, Duško, KUHAR, Urška, LACHISH, Marva, JANEŽIČ, Sandra, ŠTRBENC, Malan, KRAPEŽ, Uroš, JERALA, Roman, ATLAS, Daphne, MANČEK KEBER, Mateja. TXM peptides inhibit SARS-CoV-2 infection, syncytia formation, and lower inflamatory consequences. Antiviral research. 2024, 222, 105806, 1-13.
    13. PLAPER, Tjaša, MERLJAK, Estera, FINK, Tina, SATLER Tadej, LJUBETIČ, Ajasja, LAINŠČEK, Duško, JAZBEC, Vid, BENČINA, Mojca, STEVANOSKA, Sintija, DŽEROSKI, Sašo, JERALA, Roman. Designed allosteric protein logic. Cell Discovery 10, 8 (2024).
    14. SATLER, Tadej, HADŽI, San, JERALA, Roman. Crystal structure of de novo designed coiled-coil protein origami triangle. Journal of the American Chemical Society. 2023, 145, 31, 16995–17000.
    15. RIHTAR, Erik, LEBAR, Tina, LAINŠČEK, Duško, KORES, Katarina, LEŠNIK, Samo, BREN, Urban, JERALA, Roman. Chemically inducible split protein regulators for mammalian cells. Nature chemical biology. 2023, 19, 64-71.
    16. RAMŠAK, Maruša, RAMIREZ, Dominique A., HOUGH, Loren E., SHIRTS, Michael R., VIDMAR, Sara, ELERŠIČ FILIPIČ, Kristina, ANDERLUH, Gregor, JERALA, Roman. Programmable de novo designed coiled coil-mediated phase separation in mammalian cells. Nature communications. 2023, 14, 7973, 1-15.
    17. LAINŠČEK, Duško, GOLOB URBANC, Anja, MIKOLIČ, Veronika, PANTOVIĆ, Jelica, MALENŠEK, Špela, JERALA, Roman. Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor. Molecular therapy oncolytics. 2023, 29, 77-90.
    18. MERLJAK, Estera, MALOVRH, Benjamin, JERALA, Roman. Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation. Nature communications. 2023, 14, 1-12.
    19. AUPIČ, Jana, LAPENTA, Fabio, STRMŠEK, Žiga, MERLJAK, Estera, PLAPER, Tjaša, JERALA, Roman. Metal ion-regulated assembly of designed modular protein cages. Science advances. 2022, 8, 24, 1-12.
    20. AUPIČ, Jana, STRMŠEK, Žiga, LAPENTA, Fabio, Pahovnik, David, Pisanski, Tomaž, DROBNAK, Igor, LJUBETIČ, Ajasja, JERALA, Roman. Designed folding pathway of modular coiled-coil-based proteins. Nature communications. 2021, 12, 1-12.
    21. LAPENTA Fabio, AUPIČ Jana, VEZZOLI Marco, STRMŠEK Žiga, Da Vela Stefano, Svergun Dmitri, Carazo Jose Maria, Melero, Roberto, JERALA Roman. Self-assembly and regulation of protein cages from pre-organised coiled-coil modules. Nature Communications. 2021, 12(1):939.
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